Is ASEAN Learning from the Experience of the European Civil Protection Mechanism?

Why, following the EU’s first attempts at advancing community cooperation in civil protection and the creation of the EU civil protection mechanism, has ASEAN undertaken new initiatives, such as the adoption of a legally binding accord, AADMER and a formal institution, the AHA Center, largely comparable to the institutional innovations endorsed by the EU, in the same issue area? Can these developments be interpreted simply as the result of independent decision-making by ASEAN or are they at least a partial outcome of a transfer process? The aim of this study is to contribute to the emerging debate on European influence in Southeast Asia, taking into account how processes of policy and institutional transfer may lead ASEAN’s region builders to learn from the EU’s experience. Specifically, by discussing the case of disaster management, which has remained largely unexplored by comparative IR literature, this study argues that independent problem solving does not offer an adequate explanation of ASEAN’s developments. Conversely, lesson drawing and emulation are suggested as the two most relevant underlying mechanisms which can explain the gradual and selective adoption of an EU-like model of disaster cooperation

Building the ASEAN Center for Humanitarian Assistance and Emergency Response: is ASEAN learning from the experience of the European Civil Protection Mechanism?

Why, following the EU’s first attempts at advancing community cooperation in civil protection and the creation of the EU civil protection mechanism, has ASEAN undertaken new initiatives, such as the adoption of a legally binding accord, AADMER and a formal institution, the AHA Center, largely comparable to the institutional innovations endorsed by the EU, in the same issue area? Can these developments be interpreted simply as the result of independent decision-making by ASEAN or are they at least a partial outcome of a transfer process? The aim of this study is to contribute to the emerging debate on European influence in Southeast Asia, taking into account how processes of policy and institutional transfer may lead ASEAN’s region builders to learn from the EU’s experience. Specifically, by discussing the case of disaster management, which has remained largely unexplored by comparative IR literature, this study argues that independent problem solving does not offer an adequate explanation of ASEAN’s developments. Conversely, lesson drawing and emulation are suggested as the two most relevant underlying mechanisms which can explain the gradual and selective adoption of an EU-like model of disaster cooperation

United States and European Union Evolving Approaches in Southeast Asia: Moving Closer to Convergence or Divergence?

With the launch of Barack Obama’s strategic rebalance to Asia-Pacific, there has been a widening of the United States’ military, economic, and diplomatic presence in the Southeast Asian region. Likewise, it is clear that Southeast Asia is currently a region of relevant interest for both the United States and the European Union (EU). Surprisingly, however, up to the present, a systematic comparison of their approaches in the region has been largely lacking. To fill this void, this article compares US and EU interests, strategies, and main instruments of cooperation in Southeast Asia. Special attention is paid to the main developments that occurred in the United States, from Obama’s announcement of a strategic rebalance to Asia-Pacific to Donald Trump's National Security Strategy, and in the EU, with the release there of the 2012 "Updated East Asia Policy Guidelines." Examining whether the EU and the United States are moving towards a greater convergence of intent is of crucial importance for identifying opportunities for the further development of the transatlantic relationship in Southeast Asia. This article argues, though, that despite some apparent common traits in the US’s and the EU’s intentions, their strategies and instruments ultimately differ substantially - reflecting divergent paths. This creates crucial impediments to any further development of transatlantic cooperation in Southeast Asia

Building the ASEAN Center for humanitarian assistance and emergency response : is ASEAN learning from the experience of the European civil protection mechanism?

Why, following the EU’s first attempts at advancing community cooperation in civil protection and the creation of the EU civil protection mechanism, has ASEAN undertaken new initiatives, such as the adoption of a legally binding accord, AADMER and a formal institution, the AHA Center, largely comparable to the institutional innovations endorsed by the EU, in the same issue area? Can these developments be interpreted simply as the result of independent decision-making by ASEAN or are they at least a partial outcome of a transfer process? The aim of this study is to contribute to the emerging debate on European influence in Southeast Asia, taking into account how processes of policy and institutional transfer may lead ASEAN’s region builders to learn from the EU’s experience. Specifically, by discussing the case of disaster management, which has remained largely unexplored by comparative IR literature, this study argues that independent problem solving does not offer an adequate explanation of ASEAN’s developments. Conversely, lesson drawing and emulation are suggested as the two most relevant underlying mechanisms which can explain the gradual and selective adoption of an EU-like model of disaster cooperation.peer-reviewe

Predicting the artificial immunity induced by RUTI® vaccine against tuberculosis using universal immune system simulator (UISS)

BACKGROUND: Tuberculosis (TB) represents a worldwide cause of mortality (it infects one third of the world's population) affecting mostly developing countries, including India, and recently also developed ones due to the increased mobility of the world population and the evolution of different new bacterial strains capable to provoke multi-drug resistance phenomena. Currently, antitubercular drugs are unable to eradicate subpopulations of Mycobacterium tuberculosis (MTB) bacilli and therapeutic vaccinations have been postulated to overcome some of the critical issues related to the increase of drug-resistant forms and the difficult clinical and public health management of tuberculosis patients. The Horizon 2020 EC funded project "In Silico Trial for Tuberculosis Vaccine Development" (STriTuVaD) to support the identification of new therapeutic interventions against tuberculosis through novel in silico modelling of human immune responses to disease and vaccines, thereby drastically reduce the cost of clinical trials in this critical sector of public healthcare

Consequences of Daily Administered Parathyroid Hormone on Myeloma Growth, Bone Disease, and Molecular Profiling of Whole Myelomatous Bone

Induction of osteolytic bone lesions in multiple myeloma is caused by an uncoupling of osteoclastic bone resorption and osteoblastic bone formation. Current management of myeloma bone disease is limited to the use of antiresorptive agents such as bisphosphonates.We tested the effects of daily administered parathyroid hormone (PTH) on bone disease and myeloma growth, and we investigated molecular mechanisms by analyzing gene expression profiles of unique myeloma cell lines and primary myeloma cells engrafted in SCID-rab and SCID-hu mouse models. PTH resulted in increased bone mineral density of myelomatous bones and reduced tumor burden, which reflected the dependence of primary myeloma cells on the bone marrow microenvironment. Treatment with PTH also increased bone mineral density of uninvolved murine bones in myelomatous hosts and bone mineral density of implanted human bones in nonmyelomatous hosts. In myelomatous bone, PTH markedly increased the number of osteoblasts and bone-formation parameters, and the number of osteoclasts was unaffected or moderately reduced. Pretreatment with PTH before injecting myeloma cells increased bone mineral density of the implanted bone and delayed tumor progression. Human global gene expression profiling of myelomatous bones from SCID-hu mice treated with PTH or saline revealed activation of multiple distinct pathways involved in bone formation and coupling; involvement of Wnt signaling was prominent. Treatment with PTH also downregulated markers typically expressed by osteoclasts and myeloma cells, and altered expression of genes that control oxidative stress and inflammation. PTH receptors were not expressed by myeloma cells, and PTH had no effect on myeloma cell growth in vitro.We conclude that PTH-induced bone formation in myelomatous bones is mediated by activation of multiple signaling pathways involved in osteoblastogenesis and attenuated bone resorption and myeloma growth; mechanisms involve increased osteoblast production of anti-myeloma factors and minimized myeloma induction of inflammatory conditions

Congenital myopathies: Clinical phenotypes and new diagnostic tools

Congenital myopathies are a group of genetic muscle disorders characterized clinically by hypotonia and weakness, usually from birth, and a static or slowly progressive clinical course. Historically, congenital myopathies have been classified on the basis of major morphological features seen on muscle biopsy. However, different genes have now been identified as associated with the various phenotypic and histological expressions of these disorders, and in recent years, because of their unexpectedly wide genetic and clinical heterogeneity, next-generation sequencing has increasingly been used for their diagnosis. We reviewed clinical and genetic forms of congenital myopathy and defined possible strategies to improve cost-effectiveness in histological and imaging diagnosis

A Conserved Developmental Patterning Network Produces Quantitatively Different Output in Multiple Species of Drosophila

Differences in the level, timing, or location of gene expression can contribute to alternative phenotypes at the molecular and organismal level. Understanding the origins of expression differences is complicated by the fact that organismal morphology and gene regulatory networks could potentially vary even between closely related species. To assess the scope of such changes, we used high-resolution imaging methods to measure mRNA expression in blastoderm embryos of Drosophila yakuba and Drosophila pseudoobscura and assembled these data into cellular resolution atlases, where expression levels for 13 genes in the segmentation network are averaged into species-specific, cellular resolution morphological frameworks. We demonstrate that the blastoderm embryos of these species differ in their morphology in terms of size, shape, and number of nuclei. We present an approach to compare cellular gene expression patterns between species, while accounting for varying embryo morphology, and apply it to our data and an equivalent dataset for Drosophila melanogaster. Our analysis reveals that all individual genes differ quantitatively in their spatio-temporal expression patterns between these species, primarily in terms of their relative position and dynamics. Despite many small quantitative differences, cellular gene expression profiles for the whole set of genes examined are largely similar. This suggests that cell types at this stage of development are conserved, though they can differ in their relative position by up to 3–4 cell widths and in their relative proportion between species by as much as 5-fold. Quantitative differences in the dynamics and relative level of a subset of genes between corresponding cell types may reflect altered regulatory functions between species. Our results emphasize that transcriptional networks can diverge over short evolutionary timescales and that even small changes can lead to distinct output in terms of the placement and number of equivalent cells